All ingredients ready? Let's begin!
In a large skillet over medium-high heat, warm 2 tablespoons of the olive oil. Add the onions and bell peppers. Sauté until wilted, stirring often, and cooked through, approximately 7 minutes.
Add the chili powder, cumin, salt, and garlic powder to the onions and peppers. Warm through until the spices are fragrant.
Add the jalapeño peppers, shrimp, and lime juice to the pan and cook until the shrimp is just opaque, approximately 2 to 3 minutes. Transfer the shrimp mixture to a bowl.
Wipe out the pan with a paper towel. Return it to the heat and add a little bit of the remaining olive oil. Place a tortilla in the pan. Fill one half of the tortilla with some of the shrimp and vegetables. Top with 1/2 cup of the cheese and 1/2 teaspoon of minced cilantro.
Fold the empty side of the tortilla over the filling. Cook for about 4 minutes until the bottom is golden brown. Flip and cook the other side until the cheese melts and the tortilla is golden. Repeat until all the quesadillas are cooked. You can likely cook 2 at a time.
Serve the quesadillas with napkins and the toppings on the side.