Preheat your oven to 400°F. Pat the tilapia fillets dry with paper towels and set them aside to come to room temperature.
In the bowl of a food processor, add the tortilla chips, jalapeno, parsley, garlic powder, chili powder, and cayenne. Pulse until you have a coarse mixture, not a fine powder. Place the crust mixture in a shallow bowl or on a plate.
Whisk the egg and place it in a shallow bowl.
Lightly coat a baking sheet with vegetable oil. Alternatively, line the sheet pan with parchment paper.
Dip the tilapia fillets in the egg.
Then dip one side of the fillets into the tortilla coating, making sure to press the coating into the flesh so it sticks. Press any extra coating into the fillets. Place the fillets, crusted side facing up, on the baking sheet.
Place the pan in the oven and bake for 15 minutes until the fish is cooked through and the crust is golden brown.
Serve while hot with lime wedges and tartar sauce on the side.